BARKER LAB
  • Home
  • About
  • Contact Us
  • Lab members
BARKER LAB
Biology, Genomics, and Pathogenesis of Valley Fever

The Barker Laboratory studies Coccidioides, the fungal pathogen that causes Valley fever, an emerging infectious disease of growing public health importance in the Americas. Our research integrates genomics, ecology, immunology, microbiology, and experimental infection models to understand how this remarkable pathogen survives in the environment, causes disease, and evolves over time.
Led by Dr. Bridget M. Barker, Professor of Biological Sciences at Northern Arizona University, the laboratory investigates fundamental questions in fungal biology while developing new approaches for disease prevention and treatment. We combine comparative genomics, molecular genetics, microbiome studies, and preclinical models to identify mechanisms of pathogenesis, characterize fungal diversity, and support the development of vaccines and immunotherapies against Valley fever.

Barker Lab@PMI
@DrValleyFever on BlueSky

CURRENT PROJECTS

CRISPR technology and molecular biology

Picture
The Barker group is now funded by two U19 grants from NIH/NIAID. The work supports several institutions, including NAU, UCSF, UC-Berkeley and UC-Davis. For more information see NIH reporter:
​U19 UCSF
U19 NAU Core​
U19 NAU Project 1

Soil Ecology and Prevalence and Prediction of Valley Fever

Picture
An ABOR funded grant with our sister Arizona institutions ASU and UA will allowed us to monitor Coccidioides in soil over a 3 year period, including data from soil, air and patients.

Morphological switching and Implications for Virulence

Picture
The ability of Coccidioides to change morphology in response to environmental changes has implications for infection and sexual recombination. 
Students
Students interested in graduate studies see NAU grad college and contact Dr Barker for more information. Currently we are not accepting new graduate students, but will consider for FALL 2027

​Undergraduate students please apply through the PMI website, and specify interest in Coccidioides research.
News!
Science Article

Nature Article​

​Vox video

I'm huge in Canada

Vaccines​
Publications
All pubs at GOOGLE SCHOLAR
​
​Kala M, Ndiaye MDB, Kelley E, Harvey M, Babur F, Grischo G, Marshall JS, Yi J, Engelbrektson AL, Altin JA, Barker BM, Keim P, Knox KS, Settles EW. Identification of Coccidioidomycosis immunoreactive peptides that recall T-cell responses indicating past exposure. J Infect Dis. 2025 Mar 17:jiaf118. doi: 10.1093/infdis/jiaf118. Epub ahead of print. PMID: 40094390.
Current Research Areas
Fungal Genomics and Evolution

Using population and comparative genomics to understand the evolution, diversity, adaptation, and emergence of Coccidioides and related fungal pathogens.
Vaccines and Immunotherapy
Identifying protective immune responses and fungal antigens that can be leveraged to develop next-generation vaccines and immune-based therapies against Valley fever.
Ecology and Environmental Detection
Investigating the environmental niche of Coccidioides and developing molecular tools to predict, detect, and monitor the fungus in natural ecosystems.
Host–Pathogen Interactions
Determining how fungal pathogens interact with the immune system and identifying mechanisms that lead to either protective immunity or severe disease.
Fungal Genetics and Molecular Biology
​Developing and applying genetic and genomic tools to uncover the molecular basis of fungal growth, morphology, virulence, and adaptation.
Picture
Picture

If you are interested in joining our lab group, We are considering NEW graduate students for enrollment in FALL 2027. Email

Home      About

Proudly powered by Weebly
  • Home
  • About
  • Contact Us
  • Lab members